To the Editor With interest and concern we read the Original Investigation in a recent issue of JAMA Internal Medicine by Agar and colleagues1 titled “Efficacy of Oral Risperidone, Haloperidol, or Placebo for Symptoms of Delirium Among Patients in Palliative Care: A Randomized Clinical Trial.” Agar and colleagues1 basically demonstrate that nonpharmacological delirium treatment is better than treatment with antipsychotics, and although we appreciate the trial outline and careful execution, we have 3 major concerns.
Bogman ACCF, Schieveld JNM. Neuroleptics for Delirium: More Research Is Needed. JAMA Intern Med. 2017;177(7):1053. doi:10.1001/jamainternmed.2017.1786