The systematic review and meta-analysis by Wang et al1 focuses on an important issue: assessing the contribution of GERD in noncardiac chest pain (NCCP) by administering short-term, high-dose PPIs. Noncardiac chest pain is a common condition with significant morbidity and economic implications. Unfortunately, the studies included in the meta-analysis were small, and their findings may not be generalizable.
Bobba RK, Arsura EL. Noncardiac Chest Pain and Proton Pump Inhibitors. Arch Intern Med. 2006;166(2):248. doi:10.1001/archinte.166.2.248-a