We thank Friedman for his comments. He raises several important points, to which we have the following responses.
First, while antipsychotic agents are used for a variety of indications, our article focused exclusively on the development of parkinsonism among older adults with dementia. The use of antipsychotics in this patient population is very common but increasingly questioned because of concerns about efficacy and safety.1,2 We specifically excluded individuals with evidence of parkinsonism at baseline and therefore cannot comment on the use of antipsychotics beyond the group included in our study.
Gill S, Marras C, Anderson GM, Lee PE, Gurwitz JH, Rochon PA. Atypical Antipsychotics Have Very Different Adverse Effect Profiles and Should Not Be Lumped Together—Reply. Arch Intern Med. 2006;166(5):586-587. doi:10.1001/archinte.166.5.586-b