Copyright 2006 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.2006
We read with great interest the article by Hansen et al,1 which, to our knowledge, is the first published attempt to assess the recovery from a variety of statin-associated muscle disorders. We would like to add to their report observations from a statin myopathy clinic that currently follows over 200 patients with these disorders.
The article's primary finding, that this heterogeneous group of patients ex perienced full resolution of their pain on cessation of statin therapy, conflicts with our observations.2,3 Hansen et al1 grouped patients with a number of statin-induced muscle disorders together. In our subjects, underlying metabolic muscle disorders and the persistence of weakness is greater in patients with statin-associated rhabdomyolysis than in patients with normal creatine kinase myopathy.4 Patients often experience myalgias and demonstrate abnormalities in cardiopulmonary exercise for years after myositis, while complete resolution of myalgias is typical in patients without elevated creatine kinase levels.3 Furthermore, while muscle biopsy results in patients with normal creatine kinase myopathy may improve after the myalgias resolve, the tissue often remains myopathic.5
Phillips PS, Haas RH. Observations From a Statin Myopathy Clinic. Arch Intern Med. 2006;166(11):1232-1233. doi:10.1001/archinte.166.11.1232-b