Monosomy X, or Turner syndrome (TS), affects approximately 1 in 2000 live female births. Most individuals with TS experience ovarian failure at an early age and require estrogen therapy (ET) to induce and maintain feminization. Estrogen is also required for girls and young women to build and maintain good skeletal mineralization. During the course of our TS natural history protocol conducted at the National Institutes of Health Clinical Research Center, Bethesda, Md, we have surveyed women with TS aged 18 to 50 years regarding current estrogen use. There were 20 to 30 new study subjects in this age group who enrolled in the study in each of the calendar years from 2001 to 2005. The survey results are given in the Table.
Bondy CA, Ceniceros I, Lange E, Bakalov VK. Declining Estrogen Use in Young Women With Turner Syndrome. Arch Intern Med. 2006;166(12):1322. doi:10.1001/archinte.166.12.1322-a