We thank Pletcher for his comments and agree that additional information on the association between optimism and all-cause and noncardiovascular mortality is informative. Because depressive symptoms are related to a higher risk of cardiovascular mortality1 and optimism has been found to be related especially to a lower risk of cardiovascular morbidity and mortality,2,3 we had a priori reasons to analyze cardiovascular death in relation to optimism in our study.
Giltay EJ, Zitman FG, Kromhout D. What About Other Causes of Death?—Reply. Arch Intern Med. 2006;166(14):1528-1529. doi:10.1001/archinte.166.14.1528-c