I read with interest the article in which Qiu et al1 report that heart failure was associated with an increased risk of dementia and Alzheimer disease in a cohort of individuals 75 years or older. This relationship was offset in those receiving antihypertensive medication, 82.9% of whom were given diuretics.1 Even though the study was well designed and the results were analyzed appropriately, these findings require confirmation, since they are novel.
Reyes AJ. Heart Failure, Dementia, and Diuretics: Is Uric Acid Involved?. Arch Intern Med. 2006;166(20):2286. doi:10.1001/archinte.166.20.2286