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Editor's Correspondence
November 13, 2006

Heart Failure, Dementia, and Diuretics: Is Uric Acid Involved?

Arch Intern Med. 2006;166(20):2286. doi:10.1001/archinte.166.20.2286

I read with interest the article in which Qiu et al1 report that heart failure was associated with an increased risk of dementia and Alzheimer disease in a cohort of individuals 75 years or older. This relationship was offset in those receiving antihypertensive medication, 82.9% of whom were given diuretics.1 Even though the study was well designed and the results were analyzed appropriately, these findings require confirmation, since they are novel.

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