We greatly appreciate the interest and commentary by Cervia et al in response to our article. We agree that the reemergence of gram-negative organisms as increasingly common causes of health care–acquired bloodstream infections is very troubling, particularly given the dearth of new antibiotic development in the past several years.1 Recent work has underscored the unique challenges of developing new agents effective against some of the most worrisome gram-negative pathogens such as Pseudomonas aeruginosa and Acinetobacter baumanii.2 The urgency of this issue is highlighted even more by the continued increases in multidrug resistance among these organisms.
Lautenbach E, Fishman NO. Water as a Source of Health Care–Associated Infections—Reply. Arch Intern Med. 2007;167(1):92-93. doi:10.1001/archinte.167.1.92-b