Controversies in Internal Medicine
February 26, 2007

Coming Clean With Antibiotic Prophylaxis for Infective Endocarditis

Author Affiliations

Author Affiliation: Department of Medicine, McMaster University, Hamilton, Ontario.


Copyright 2007 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.2007

Arch Intern Med. 2007;167(4):330-332. doi:10.1001/archinte.167.4.330

Infective endocarditis (IE) is a potentially catastrophic disease that was uniformly fatal in the preantibiotic era, and it still carries an unacceptably high rate of morbidity and mortality. Such a sinister disease warrants attempts at prevention. However, prevention of IE with antibiotics is neither reasonable nor possible in the foreseeable future and results in considerable harm.

Several preconditions are necessary for antibiotic prophylaxis (AP) to be the right approach to IE prevention: First, inciting events must be identified as a target of prophylaxis. Second, a subset of the population at increased risk of developing IE and undergoing the inciting event must be identified. Third, a simple, efficacious, and effective method of AP must be identified. Finally, the resultant net health of the population receiving AP must be better than if they had not received it.

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