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Editorial
June 11, 2007

Chronic Kidney DiseaseCause and Consequence of Cardiovascular Disease

Arch Intern Med. 2007;167(11):1113-1115. doi:10.1001/archinte.167.11.1113

The widely held view that albuminuria and/or reduced glomerular filtration rate (GFR) inexorably progress to end-stage renal disease (ESRD) requiring kidney replacement therapy is not uniformly accurate. Inadequately treated nephropathy risk factors in those with chronic kidney disease (CKD) such as hyperglycemia, hypertension, and proteinuria often lead to declining kidney function. However, the number of individuals at risk for ESRD by virtue of having CKD demonstrates that only a minority reach ESRD.1 Indeed, most will ultimately die of cardiovascular disease (CVD) before needing renal replacement therapy.2

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