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Editor's Correspondence
October 8, 2007

High-Sensitivity C-Reactive Protein and Prediction of Nontraumatic Fractures

Arch Intern Med. 2007;167(18):2007. doi:10.1001/archinte.167.18.2007-b

Schett and colleagues1 found that the high-sensitivity C-reactive protein (hs-CRP) level was a significant and independent risk predictor of nontraumatic fracture in the Bruneck study. This conclusion was mainly based on the higher incidence of nontraumatic fracture and odds ratio in the highest tertile group of hs-CRP.1 However, using the odds ratio in gauging the performance of prognostic marker has limitations.2 The receiver operating characteristics curve was recommended to assess the predictor or new marker.24 It would be helpful for readers to decide whether hs-CRP level could be used as a new predictor for nontraumatic fracture if the receiver operating characteristic curve of hs-CRP were analyzed and reported in their study.1

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