The primary aim of our study was to test whether low-grade systemic inflammation as estimated by hs-CRP level is linked to the risk of nontraumatic fractures.1 The hypothesis that inflammation interferes with bone metabolism and affects fracture risk is intriguing from a pathophysiologic and therapeutic viewpoint. Our and other recent epidemiological data1,2 support this view and intend to stimulate further research efforts in the field.
Schett G, Kiechl S. High-Sensitivity C-Reactive Protein and Prediction of Nontraumatic Fractures—Reply. Arch Intern Med. 2007;167(18):2007-2008. doi:10.1001/archinte.167.18.2007-c