We read with interest the article by Kurth et al1 on the association between migraine and increased risk of CVD in men. In a previous study, the authors have reported an association among active migraine with aura and increased risk of CVD, CHD, and ischemic stroke in women.2 The biological link between migraine and CVD and CHD is complex and currently unclear. Several mechanisms may be involved such as prothrombotic and vasoactive factors.
Perciaccante A, Fiorentini A, Valente R, Granata M, Tubani L. Migraine and Heart Rate Variability. Arch Intern Med. 2007;167(20):2264. doi:10.1001/archinte.167.20.2264-a