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Richards and colleagues1 concluded that daily use of SSRIs in adults 50 years and older remained associated with a 2-fold increased risk of clinical fragility fracture after adjustment for potential confounders. The authors stated that a potential weakness of this study was the lack of evaluation of the subjects by a psychiatrist and that, instead, symptoms of depression were evaluated by using the Mental Component Scale and the mental health inventory 5 scales of the medical outcomes study.
O’Brien SM. A Possible Role of Recurrent Major Depression in Risk of Fracture. Arch Intern Med. 2007;167(21):2370. doi:10.1001/archinte.167.21.2370-a