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Editor's Correspondence
November 26, 2007

A Possible Role of Recurrent Major Depression in Risk of Fracture—Reply

Arch Intern Med. 2007;167(21):2370-2371. doi:10.1001/archinte.167.21.2370-b

In reply

We are pleased that our study1 has generated interest from our colleagues and appreciate the opportunity to respond to their queries related to our study, which addressed the relationship between SSRI use and the risk of fragility fracture. Ziere and colleagues have correctly pointed out that Cox proportional hazards models can be used when the time to event is known. Indeed, although the subjects in the Canadian Multicentre Osteoporosis Study (CaMos) trial reported their events on a yearly basis, they were also asked to report the date of the event during the preceding year, which was used for analysis. The timing of this event was also verified when the radiographs of fractures were verified. There were 335 radiologically confirmed clinical fragility fractures included in the study.

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