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Editor's Correspondence
November 26, 2007

A Possible Overestimation of the Effect of Aspirin

Arch Intern Med. 2007;167(21):2372-2373. doi:10.1001/archinte.167.21.2372-b

In their nested case-control study on aspirin use and mortality in women within the Nurses Health Study, Chan et al1 conclude that aspirin use is associated with a decreased mortality. The reported effect is clearly stronger than results of previous randomized controlled trials suggested. The effect of aspirin in this study may be overestimated for 2 reasons that are remediable.

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