Weinreb and colleagues correctly point out that many cases of GD type 3 involve seriously ill children with multiple symptoms affecting the hematopoietic, lymphatic, and the neurological organ systems. In our study, we assessed risk of malignant disease among adult (age ≥18 years) male military veterans admitted to VA hospitals with a GD diagnosis.1 Individuals with early-onset severe GD are likely not included in this study because they were almost certainly disqualified from military service in younger years.
Landgren O, Gridley G, Caporaso NE, Turesson I. Prevalence of Type 1 Gaucher Disease in the United States—Reply. Arch Intern Med. 2008;168(3):327-328. doi:10.1001/archinternmed.2007.92