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Editor's Correspondence
March 10, 2008

Is Aspirin Resistance Due to Noncompliance?

Arch Intern Med. 2008;168(5):550. doi:10.1001/archinte.168.5.550

The systematic review and meta-analysis of aspirin resistance by Snoep et al1 found that patients with laboratory resistance to aspirin also have clinical resistance to aspirin as evidenced by higher risks of recurrent cardiovascular events. A very likely explanation of this association is that laboratory resistance and clinical resistance have the same cause—noncompliance.2

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