The Women's Antioxidant Cardiovascular Study (WACS) was conducted to evaluate the effects of antioxidant vitamins on the risk of cardiovascular events.1 Regarding the limitations of this study, apart from the lack of complete follow-up and compliance reported by the authors, some other points should have been discussed. First, only women were included in the trial. No information about premenopausal or postmenopausal status of the study population was given. Moreover, dietary habits of the participants were not taken into account, despite the fact that antioxidant clinical studies should investigate the impact of a rich-in-antioxidant-nutrients diet in conjunction with the administration of vitamin supplements, as mentioned in the introduction.
Katsiki N, Manes C. Clinical Trials of Antioxidant Supplementation in the Prevention of Cardiovascular Events. Arch Intern Med. 2008;168(7):773. doi:10.1001/archinte.168.7.773-a