In the interesting article by Kellum et al1 on the systemic cytokine response to pneumonia in a cohort study of 1886 subjects hospitalized for community-acquired pneumonia (CAP), the authors report that the highest risk of death was with combined high levels of the proinflammatory cytokine interleukin (IL)-6 and the anti-inflammatory cytokine IL-10. They conclude that mortality is highest when both anti-inflammatory and proinflammatory cytokine levels are high.
White M, Mankan A, Lawless MW, O’Dwyer MJ, McManus R, Ryan T. Mortality in Humans With Pneumonia and Sepsis Is Related to an Uncompensated Anti-inflammatory Response to Infection. Arch Intern Med. 2008;168(13):1468-1469. doi:10.1001/archinte.168.13.1468-b