Invited Commentary
December 14, 2009

Antidepressant Use, Depression, and Poor Cardiovascular Outcomes: The Chicken or the Egg?Comment on “Antidepressant Use and Risk of Incident Cardiovascular Morbidity and Mortality Among Postmenopausal Women in the Women's Health Initiative Study”

Author Affiliations

Copyright 2009 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.2009

Arch Intern Med. 2009;169(22):2140-2141. doi:10.1001/archinternmed.2009.437

Depression is a common comorbidity in patients with chronic heart failure, with reported incidence as high as approximately 48% in this patient population.14 Studies have shown that depression in patients with heart failure is strongly associated with worse outcomes and is an independent predictor of increased mortality and hospitalization.59 As a result, the use of antidepressants in this population has become more prevalent.

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