In the December 14, 2009, issue, McCullough et al1 presented a systematic review of randomized trials that used coronary artery calcification (CAC) progression as the primary end point. Despite the noninclusion of 2 eligible randomized placebo-controlled trials,2,3 we agree with their assertion that CAC progression has not been consistently reduced in any therapeutic randomized trial to date.
McEvoy JW, Blaha MJ. Progression of Coronary Artery Calcification: Not Down-and-Out. Arch Intern Med. 2010;170(8):735-736. doi:10.1001/archinternmed.2010.60