We thank Dr Rastegar for sharing this interesting case. Some cases of esophageal cancer in HIV-infected individuals may well be linked to HPV infection. We observed 1 HIV-infected individual who had an HPV-related condyloma of his esophagus (Figure), who was not included in our published series because we only included cases of invasive esophageal carcinoma. Others have reported similar individuals with HPV-related esophagitis.1 Recent published data support an association between high-risk HPV and esophageal carcinomas,2,3 although causation is not established and is controversial.
Pantanowitz L, Bower M, Krown SE, Stebbing J. HIV Infection and Esophageal Cancer—Reply. Arch Intern Med. 2010;170(10):916-917. doi:10.1001/archinternmed.2010.114