I am writing in response to the editorial titled “Preventing Cognitive Declines in Usual Aging” by Espeland and Henderson.1 Prevention of mild cognitive declines preceding diagnosable Alzheimer disease (AD) and declines in AD dementia will probably be most effective when the intervention targets a process closely relevant to the disease pathogenesis.1 Oxidative stress changes have been shown to precede the cardinal neuropathologic manifestations of AD.2 Therapy for AD focuses mainly on the hypotheses that amyloid and the tubular tau proteins are at the core of the disease.
Waugh WH. Cognitive Declines Therapy by Iron Burden Reduction. Arch Intern Med. 2007;167(10):1098. doi:10.1001/archinte.167.10.1098-a