In the April 26, 2010, issue of the Archives, Stockl et al1 reported a clinically significant drug interaction between clopidogrel and proton pump inhibitors (PPIs) based on their retrospective cohort study of health insurance claims. Their study concluded that concomitant clopidogrel and PPI use was associated with higher rates of hospitalization for myocardial infarction (MI) or coronary stent placement. However, there is more recent evidence that contradicts their conclusion and was not discussed in their article.
Chua D, Shalansky SJ, Legal MG, Jung J. Conflicting Evidence Surrounding the Clopidogrel and Proton Pump Inhibitor Drug Interaction. Arch Intern Med. 2010;170(16):1507-1508. doi:10.1001/archinternmed.2010.299