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Rose and colleagues1 reported intriguing results showing that elevated chocolate intake was found in individuals with probable major depression (as defined by a Center for Epidemiologic Studies Depression Scale [CES-D] score of ≥22), whatever the sex of the individual.
Although one review has already concluded that there is no evidence that chocolate has a significant impact on depression,2 the interrelationship among elevated chocolate intake, depression, and clinical progression of human immunodeficiency virus (HIV) or hepatitis C virus (HCV) may be particularly fascinating in the HIV-HCV–positive population for several reasons. These individuals have a history of drug injection and/or alcohol abuse, which may both be detrimental to HIV treatment adherence and response.
Carrieri MP, Cohen J, Winnock M, Salmon D. Chocolate Intake, Depression, and Clinical Progression in HIV-HCV Coinfected Patients: Still More Questions Than Answers. Arch Intern Med. 2010;170(17):1607. doi:10.1001/archinternmed.2010.330