Additional Information: Drs Leontiadis and Howden have collaborated on systematic reviews and meta-analyses on the role of PPIs in ulcer bleeding for the Cochrane Collaboration.
In their recent meta-analysis, Wang and colleagues concluded that high-dose intravenous proton pump inhibitor (PPI) regimens were not superior to non–high-dose regimens for patients with recent ulcer bleeding.1 However, we consider these conclusions to be premature, possibly flawed, and potentially misleading.
Leontiadis GI, Howden CW. Proton Pump Inhibitor Dose for Ulcer Bleeding: Is Less Really More?. Arch Intern Med. 2010;170(18):1697-1698. doi:10.1001/archinternmed.2010.357