Editor's Correspondence
October 11, 2010

Proton Pump Inhibitor Dose for Ulcer Bleeding: Is Less Really More?

Author Affiliations

Copyright 2010 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.2010

Arch Intern Med. 2010;170(18):1697-1698. doi:10.1001/archinternmed.2010.357

Additional Information: Drs Leontiadis and Howden have collaborated on systematic reviews and meta-analyses on the role of PPIs in ulcer bleeding for the Cochrane Collaboration.

In their recent meta-analysis, Wang and colleagues concluded that high-dose intravenous proton pump inhibitor (PPI) regimens were not superior to non–high-dose regimens for patients with recent ulcer bleeding.1 However, we consider these conclusions to be premature, possibly flawed, and potentially misleading.

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