We read with interest the meta-analysis by Wang et al.1 The authors conclude that low-dose PPIs are as effective as high-dose PPI infusion to prevent recurrent peptic ulcer bleeding. In our opinion, there are strong methodological concerns about this study that could make its results and conclusions invalid. These concerns pertain both to the studies included in the analysis and to the methods used.
Calvet X, Barkun A, Bardou M, Sung J, Kuipers EJ. High-Dose vs Non–High-Dose PPIs After Endoscopic Treatment in Patients With Bleeding Peptic Ulcer: Current Evidence Is Insufficient to Claim Equivalence. Arch Intern Med. 2010;170(18):1698-1699. doi:10.1001/archinternmed.2010.359