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Editor's Correspondence
November 22, 2010

Platelet Inhibition and Cancer Promotion

Author Affiliations

Author Affiliations: Internal Medicine, Fountain Medical Court, Bonita Springs, Florida (Dr Goldstein); Medical Service, Comando Brigata Alpina “Julia,” Udine, Italy (Dr Mascitelli); and Cardiology Service, Ospedale di Tolmezzo, Tolmezzo, Italy (Dr Pezzetta).

Arch Intern Med. 2010;170(21):1943-1944. doi:10.1001/archinternmed.2010.420

In their interesting commentary, Floyd and Serebruany1 suggest how the potent platelet inhibitor, prasugrel, might promote cancer, as was seen in a large prospective trial.2 They postulate that platelets might inhibit in situ cancer from disseminating by trapping tumor cells in capillaries, and potent platelet inhibition limits this mechanism. However, recent data suggest other plausible causes for this association.

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