In their interesting commentary, Floyd and Serebruany1 suggest how the potent platelet inhibitor, prasugrel, might promote cancer, as was seen in a large prospective trial.2 They postulate that platelets might inhibit in situ cancer from disseminating by trapping tumor cells in capillaries, and potent platelet inhibition limits this mechanism. However, recent data suggest other plausible causes for this association.
Goldstein MR, Mascitelli L, Pezzetta F. Platelet Inhibition and Cancer Promotion. Arch Intern Med. 2010;170(21):1943-1944. doi:10.1001/archinternmed.2010.420