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Editor's Correspondence
Less Is More
March 28, 2011

PSA: Possible Surgery Avoidance With Use of Free PSA

Author Affiliations

Author Affiliation: Department of Internal Medicine, Wellesley Primary Care Medicine, Wellesley, Massachusetts.

Arch Intern Med. 2011;171(6):594-595. doi:10.1001/archinternmed.2011.80

Shao and colleagues1 report that even with prostate-specific antigen (PSA) values below 4.0 ng/mL (to convert PSA to micrograms per liter, multiply by 1.0) there is a risk of prostate cancer, but detecting these cancers by lowering the PSA threshold might lead to overdiagnosis and overtreatment. They conclude that PSA level is not a sufficient basis for treatment decisions. In an accompanying Invited Commentary, Hoffman and Zeliadt2 agree that the health care challenge is to discover biomarkers that better identify the patients most likely to benefit from treatment.

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