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Editor's Correspondence
June 13, 2011

Lack of Cardiovascular Disease Among Old Order Amish With Familial Defective Apolipoprotein B

Author Affiliations

Author Affiliations: Division of Nutrition and Metabolic Diseases, Department of Internal Medicine, Center for Human Nutrition, University of Texas Southwestern Medical Center, Dallas.


Copyright 2011 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.2011

Arch Intern Med. 2011;171(11):1039-1040. doi:10.1001/archinternmed.2011.238

We read with great interest the article by Shen et al1 reporting the prevalence of familial defective apolipoprotein B-100 due to R3500Q mutation in apolipoprotein B (APOB) in the Old Order Amish population. The authors concluded that this mutation was a major determinant of low-density lipoprotein cholesterol (LDL-C) levels and coronary artery calcification in the Amish.1

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