My colleagues and I are sorry if the introduction in our article1 gave the impression that the authors of the 2009 publication by de Vries et al2 considered their findings suggestive of causality. This interpretation of their findings was solely our own. The study by de Vries2 is referred to in more detail in the “Comment” section, where we note that while the effect could not be shown to persist with longer durations of PPI treatment, most patients were coadministered PPIs for less than 12 months. We are grateful to Dr de Vries for this opportunity to clarify.
Abrahamsen B. Inverse Association Between Duration of Use of Acid-Suppressive Medications and Fracture Risk—Reply. Arch Intern Med. 2011;171(11):1044. doi:10.1001/archinternmed.2011.227