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Editor's Correspondence
July 25, 2005

Dilated Cardiomyopathy and Creutzfeldt-Jakob Disease: Evidence for a Role of Cellular Prion Protein in the Heart?

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Copyright 2005 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.2005

Arch Intern Med. 2005;165(14):1663-1664. doi:10.1001/archinte.165.14.1663-b

We read with great interest the case published by Ashwath et al.1 The authors describe a patient with new-onset dilated cardiomyopathy after Creutzfeldt-Jakob disease. An endomyocardial biopsy specimen showed abnormal prion protein (PrPSc) accumulation in muscle fibers and peripheral heart nerves. This is an important observation that might have consequences regarding the understanding of the physiological functions of cellular prion (PrPc) in the heart.

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