A 62-year-old man developed type 2 diabetes mellitus circa 1994. He was initially treated with glyburide and then with insulin. After rezulin (initial dosage, 200 mg/d; later dosage, 400 mg/d) was added to the regimen,the percentage of glycosylated hemoglobin decreased from 9.5% to 6.7% (reference range, 4.1%-6.1%). Four months after the patient started taking 400 mg/d of rezulin, he began to develop peripheral edema and his waist circumference increased. Despite the initiation of furosemide therapy (40 mg/d), he gained a total of 20 kg over approximately 4 months.
Gorson DM. Significant Weight Gain With Rezulin Therapy. Arch Intern Med. 1999;159(1):99. doi: