I read with interest the response by Dr Tice1 to Drs Joshi and Miller's2 article recently published in the ARCHIVES entitled "Doxycycline Revisited." Tice mentioned that doxycycline may be administered on a once-daily basis owing to its long serum half-life, and Dr Tice correctly pointed out a loading dose of doxycycline should be administered to achieve more rapid blood levels.
Cunha BA. Doxycycline Re-Revisited. Arch Intern Med. 1999;159(9):1006. doi: