Calcium channel blockers are commonly used to treat systemic hypertension in patients with intracranial hypertension. We describe a 35-year-old woman whose benign intracranial hypertension worsened with amlodipine therapy.
This woman first presented with headaches and was found to have papilledema with no focal neurological deficit. A computed tomographic scan of the brain was normal. A lumbar puncture showed raised cerebrospinal fluid (CSF) pressure although the results of the CSF examination were normal. Benign intracranial hypertension was diagnosed and she was managed with repeated lumbar punctures.
Gurm HS, Farooq M. Calcium Channel Blockers and Benign Hypertension. Arch Intern Med. 1999;159(9):1011. doi: