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Editor's Correspondence
November 8, 1999

Latex Agglutination Is a Valid Method for the Measurement of D-Dimer Levels

Author Affiliations

Copyright 1999 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.1999

Arch Intern Med. 1999;159(20):2485. doi:

The performance characteristics of latex agglutination tests are highly dependent on the manufacturer. Although Kutinsky et al1 are aware of this fact, they extrapolate the poor performance of the latex agglutination test used in their study to all latex agglutination tests for D-dimer levels. In fact, many latex agglutination tests have sensitivities and negative predictive values, ranging between 94% and 100%, that match or exceed those of enzyme-linked immunosorbent assays.2,3 The recommendation by the authors that latex agglutination tests not be used to evaluate patients with suspected pulmonary embolism is based on insufficient data. The Yugo was a lemon, but not all cars are poorly engineered.

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