Vitamin E has antioxidant activity that inhibits subendothelial low-density lipoprotein oxidation and atherosclerotic plaque formation.1 Nevertheless, current opinion does not advocate the use of daily vitamin E supplementation to reduce the risk of vascular events2 and the skepticism concerning the use of vitamin E as an adjunctive treatment for either secondary or primary prevention of vascular events is based on the present "lack of solid evidence of efficacy."2 However, a careful overview of the data allows for an alternative approach, which is based on several considerations.
Schattner A. To E or Not to E. Arch Intern Med. 1999;159(20):2485. doi: