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Editor's Correspondence
November 8, 1999

To E or Not to E

Author Affiliations

Copyright 1999 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.1999

Arch Intern Med. 1999;159(20):2485. doi:

Vitamin E has antioxidant activity that inhibits subendothelial low-density lipoprotein oxidation and atherosclerotic plaque formation.1 Nevertheless, current opinion does not advocate the use of daily vitamin E supplementation to reduce the risk of vascular events2 and the skepticism concerning the use of vitamin E as an adjunctive treatment for either secondary or primary prevention of vascular events is based on the present "lack of solid evidence of efficacy."2 However, a careful overview of the data allows for an alternative approach, which is based on several considerations.

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