Celecoxib (Celebrex; Searle & Co Pharmaceuticals, Skokie, Ill, and Pfizer Inc, New York, NY) is a new and popular nonsteroidal anti-inflammatory drug (NSAID) that selectively inhibits cyclooxygenase 2.1 It is approved for the treatment of both rheumatoid arthritis and osteoarthritis. Recognized adverse reactions include gastrointestinal hemorrhage, hepatitis, abdominal pain, and diarrhea. It should not be administered to patients with allergies to sulfa drugs. Acute pancreatitis has not been reported with the use of celecoxib.
Carrillo-Jimenez R, Nurnberger M. Celecoxib-Induced Acute Pancreatitis and Hepatitis: A Case Report. Arch Intern Med. 2000;160(4):553-554. doi: