We appreciate the interest and comments of Inoue and Sano regarding our recent report in which we noted 2 cases of pulmonary edema associated with the use of troglitazone.1 As they pointed out, chronic renal failure, especially when it is the result of a nephrotic syndrome, can also cause pulmonary edema in the absence of cardiac disease. Both of the patients had normal renal function as measured by serum creatinine and serum urea nitrogen levels, and neither had microalbuminuria (Table 1). Therefore, renal disease did not play a role in either of our cases.
Kelly J, Hirsch IB, Cooper S. Troglitazone-Induced Pulmonary Edema—Reply. Arch Intern Med. 2000;160(6):871-872. doi: