Randomized controlled trials are accepted as the most effective way to determine the relative efficacy of a new therapy. Nonexperimental evidence from recalled experiences generally tends to overstate drug efficacy. Favorable outcomes are more likely to be remembered by clinicians, and clinical practice is never "blind," since both patient and clinician know when active treatment is used. Evidence-based medicine de-emphasizes intuition, thereby permitting recommendations for patient treatment based on results of controlled scientific studies.1 Fudin takes issue with the results and conclusions of our study in preference to recalled clinical experience with gabapentin.
Morello CM, Leckband SG, Stoner CP, Moorhouse DF, Sahagian GA. Gabapentin vs Amitriptyline for the Treatment of Peripheral Neuropathy—Reply. Arch Intern Med. 2000;160(7):1040-1041. doi: