Many forms of cancer, such as prostate, breast, and colon cancer, can run in families. Patients with afflicted relatives often request screening, and they look to us for guidance.
A 72-year-old white man whose father died from prostate cancer had the following prostate-specific antigen (PSA) values: 1.2 ng/mL in December 1996, 1.4 ng/mL in July 1997, 1.6 ng/mL in May 1998, 1.6 ng/mL in October 1998, and 1.9 ng/mL in March 1999. At the patient's request, because of the rise in PSA levels, urological consultation was obtained, and adenocarcinoma of the prostate (Gleason score, 6) was subsequently diagnosed.
Feingold RM. Prostate Cancer Screening in High-Risk Patients. Arch Intern Med. 2000;160(8):1204. doi: