Editor's Correspondence
May 22, 2000

Thyroid Nodules and Carcinoma in Graves Disease

Author Affiliations

Copyright 2000 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.2000

Arch Intern Med. 2000;160(10):1537-1538. doi:

The article by Cantalamessa and colleagues1 points out that thyroid nodules occur with a high frequency in patients with Graves disease as determined by ultrasonography and pathological examination findings. Nevertheless, the authors discovered only 1 case of carcinoma among 315 consecutive patients (0.3%), including 106 with nodules. Surprisingly, this is a rather low frequency compared with previous studies and the findings from a recent series.2 We assume that this low frequency is the result of the fact that only 20 patients underwent surgery.

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