We read with interest the article by McMullin et al.1 They reported that a Web-based clinical information system can be an efficient method of detecting contraindicated drug combinations and avoiding potentially serious adverse drug reactions. We also believe that using computers is one of the most efficient methods to achieve this, and computerized systems have been gradually introduced in Japan. However, the following considerations should be taken into account to better detect contraindicated drug interactions: (1) clinicians should recognize and be alert to drug interactions, (2) proper information concerning drug interactions should be given to clinicians as well as pharmacists, and (3) pharmacists should properly check (with or without computers) prescriptions and provide clinicians with necessary information.
Harada K, Fujimura A. The Need for Improving Information Systems on Drug Interactions in Japan. Arch Intern Med. 2000;160(13):2061-2067. doi: