We appreciate the insight provided by Harada and Fujimura and share their concerns regarding the reliability of information surrounding drug interactions.1 Within the last decade, our understanding of the P-glycoprotein and cytochrome P450 systems has dramatically improved. Unfortunately, a disturbing number of life-threatening drug interactions also have been discovered among the medications approved by the Food and Drug Administration (FDA) during this same period.
McMullin ST. The Need for Improving Information Systems on Drug Interactions in Japan—Reply. Arch Intern Med. 2000;160(13):2061-2067. doi: