Citations 0
Editor's Correspondence
July 24, 2000

Drug-Induced Allergic Cytopenia: In Vitro Confirmation by the Lymphocyte Transformation Test—Reply

Author Affiliations

Copyright 2000 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.2000

Arch Intern Med. 2000;160(14):2219. doi:

In reply

Dr Sachs and coworkers point to 2 important and related problems that occur in the evaluation of cases of drug-induced idiosyncratic neutropenia: (1) to identify the causative drug and (2) to improve understanding of mechanism(s) for the reaction. Identification might be easy when there is only 1 drug (eg, an antithyroid or clozapine) and disease. But the clinical reality is often more complex because a number of drugs may have been used simultaneously or sequentially (eg, in an intensive care unit, where a potentially life-threatening agranulocytosis complicates an already precarious situation). Identification is then urgent because this patient population usually needs multiple courses of related drugs (eg, high-dose antibiotic treatment).1

First Page Preview View Large
First page PDF preview
First page PDF preview