We read with interest the article of Gaster and Holroyd1 on St John's wort for depression. However, the authors do not mention the substance hyperforin as a component of Hypericum extracts. Hyperforin was first mentioned,2,3 and again recently discussed,4,5 as an antibiotic.
Vormfelde SV, Poser W. Hyperforin in Extracts of St John's Wort (Hypericum perforatum) for Depression. Arch Intern Med. 2000;160(16):2546. doi: