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Editor's Correspondence
November 27, 2000

Toxic Granulation Neutrophils and C-Reactive Protein

Author Affiliations

Copyright 2000 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.2000

Arch Intern Med. 2000;160(21):3326-3327. doi:

Toxic granulation neutrophils (TGNs), which have prominent azurophilic cytoplasmic granules in blood smears stained by the Wright or May-Grünwald-Giemsa technique, appear in blood when inflammation occurs. Chemotaxis, migration, phagocytosis, bactericidal activity, and the density of surface IgG–Fc receptor III are decreased in TGNs,1 but myeloperoxidase activity and nitroblue tetrazolium reduction activity are increased.2 On the other hand, serum levels of C-reactive protein (CRP) are also increased in inflammation; CRP has an opsonic effect on phagocytosis of bacteria.3 Furthermore, toxic signs of neutrophils, such as toxic granules, Dohle bodies, and cytoplasmic vacuoles, occur in infectious diseases with high levels of CRP.4 However, there have been no reports examining the quantitative correlation between the percentage of TGNs and the concentrations of CRP.

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