Ritter and Dembicki in their letter and Cheng in his identify very important points of discussion. One concern was that some of the confounding variables inherent in the testing of plant-based medicines were not controlled in our study.1 Another was that some components of ginseng might interact with various drugs, resulting in undesirable outcomes.
Vuksan V, Sievenpiper JL. The Variable Effects of Whole-Leaf Digitalis Is a Paradigm of the Glycemic Effects of Ginseng—Reply. Arch Intern Med. 2000;160(21):3330-3331. doi: