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March 1919

BIOCHEMICAL STUDIES OF PNEUMONIC EXUDATESWITH SPECIAL REFERENCE TO THE MECHANISM OF THE CRISIS IN PNEUMONIA STUDIES IN PNEUMONIA. X

Author Affiliations

PHILADELPHIA

From the Department of Physiological Chemistry and the McManes Laboratory of Experimental Pathology of the University of Pennsylvania.

Arch Intern Med (Chic). 1919;23(3):395-408. doi:10.1001/archinte.1919.00090200128010
Abstract

In a previous communication1 we demonstrated the following properties of pneumonic lung exudates:

  1. Salt solution extracts of human lungs in the stage of gray hepatization in pneumococcus lobar pneumonia are more toxic for experimental animals than similar extracts of normal lung tissue. The method of extraction influences the toxicity of both extracts.

  2. Lethal doses of extracts of both pneumonic and normal lung tissue injected intravenously usually produce anaphylactic-like symptoms.

  3. Sterile extracts of pneumonic lung tissue of dogs removed forty-eight hours after intrabronchial insufflation of virulent pneumococci are more toxic than similar extracts of consolidated lung following intrabronchial insufflation of sterile aleuronat in suspension and both of these are somewhat more toxic than extracts of equal weights of normal dog lung.

  4. The toxicity of extracts of normal and pneumonic lung is decreased by heating, drying and filtration through porcelain filters.

  5. Extracts of human pneumonic lungs in gray hepatization are hemolytic for guinea-pig cells, whereas similar

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